Effect of Ceasing Creatine Supplementation While Maintaining Resistance Training in Older Men

J Aging Phys Act. 2004 Jul;12(3):219-31. doi: 10.1123/japa.12.3.219.

Abstract

The authors previously found that creatine (Cr) combined with 12 weeks of resistance training enhanced muscle strength and endurance and lean tissue mass (LTM) in older men. Their purpose in this study was to assess these variables with cessation of Cr combined with 12 weeks of reduced training (33% lower volume) in a subgroup of these men (n = 8, 73 years old) compared with 5 men (69 years old) who did not receive Cr. Strength (1-repetition maximum [1-RM]), endurance (maximum number of repetitions over 3 sets at 70-80% 1-RM), and LTM (dual-energy X-ray absorptiometry) were assessed before and after 12 weeks of Cr cessation combined with reduced-volume training. No changes in strength or LTM occurred. Muscle endurance was significantly reduced (7-21%; p <.05), with the rate of change similar between groups. Withdrawal from Cr had no effect on the rate of strength, endurance, and loss of lean tissue mass with 12 weeks of reduced-volume training.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Body Composition / drug effects
  • Body Composition / physiology*
  • Creatine / adverse effects*
  • Creatine / pharmacology
  • Double-Blind Method
  • Exercise / physiology*
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology*
  • Physical Endurance / drug effects
  • Physical Endurance / physiology*
  • Substance Withdrawal Syndrome / physiopathology*

Substances

  • Creatine