Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus

FEMS Microbiol Lett. 1992 Aug 15;74(2-3):259-65. doi: 10.1016/0378-1097(92)90439-u.


Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes encode efflux systems that rely on proton motive force.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents, Local / pharmacology*
  • Biological Transport, Active / genetics
  • Disinfectants / pharmacology*
  • Drug Resistance, Microbial / genetics
  • Ethidium / metabolism
  • Genes, Bacterial / physiology*
  • Humans
  • Phenotype
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Substrate Specificity / physiology


  • Anti-Infective Agents, Local
  • Disinfectants
  • Ethidium