Dipeptide binding in water by a de novo designed guanidiniocarbonylpyrrole receptor

Carsten Schmuck; Lars Geiger

doi:10.1021/ja048587v

Dipeptide binding in water by a de novo designed guanidiniocarbonylpyrrole receptor

J Am Chem Soc. 2004 Jul 28;126(29):8898-9. doi: 10.1021/ja048587v.

Authors

Carsten Schmuck¹, Lars Geiger

Affiliation

¹ Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Wuerzburg, Germany. schmuck@chemie.uni-wuerzburg.de

PMID: 15264812
DOI: 10.1021/ja048587v

Abstract

A new dipeptide receptor 9, which was designed de novo based on theoretical calculations, efficiently binds dipeptides in water with Kass > 104 M-1 by a combination of ion pairing and hydrogen bonds as can be shown by UV-titration and NMR experiments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dipeptides / chemistry*
Guanidine / analogs & derivatives*
Guanidine / chemistry
Kinetics
Models, Molecular
Protein Binding
Pyrroles / chemistry*
Receptors, Peptide / chemistry*
Water / chemistry*

Substances

Dipeptides
Pyrroles
Receptors, Peptide
Water
Guanidine