A method to quantify the uptake rate of 2-[18F]fluoro-2-deoxy-D-glucose in tissues

Nucl Med Commun. 2004 Aug;25(8):851-4. doi: 10.1097/01.mnm.0000136729.42108.1a.


A two-compartment model is used to derive the tissue time-activity curve of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG). At the later phase of the 18F-FDG activity in the tissue, the model leads to a method which allows the assessment of the 18F-FDG uptake rate constant. The proposed method is both compared with the standard uptake value (SUV) method and with Patlak's graphical analysis.

MeSH terms

  • Algorithms*
  • Animals
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Metabolic Clearance Rate
  • Models, Biological*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / metabolism*
  • Positron-Emission Tomography / methods
  • Radioisotope Dilution Technique
  • Radiopharmaceuticals / pharmacokinetics


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18