A comparison of photopic and scotopic electroretinographic changes in early diabetic retinopathy

Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2773-80.


Previous studies of early diabetic retinopathy have shown that oscillatory potential (OP) amplitudes are reduced in many diabetic patients. OP amplitude is believed to be a more sensitive indicator of the development of future retinopathy than b-wave amplitude of the scotopic electroretinogram (ERG). Because OPs measured to a bright white flash reflect both rod and cone system activity, it is important to compare OP amplitudes to photopic ERG measures as well as scotopic measures in early diabetic retinopathy. In this study, OPs and ERG responses were measured under photopic and scotopic conditions in a group of diabetic patients. Although OPs were reduced in amplitude in the diabetic group, several other parameters of the scotopic and photopic b-waves were impaired. The results indicate that b-wave activity may indicate retinal changes in early diabetic retinopathy in the same manner as the OPs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dark Adaptation
  • Diabetes Mellitus / physiopathology
  • Diabetic Retinopathy / physiopathology*
  • Electroretinography*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Photic Stimulation
  • Retina / physiopathology
  • Sensory Thresholds
  • Visual Acuity