Hyperpolarization by glucose of feeding-related neurons in snail

Acta Biol Hung. 2004;55(1-4):195-200. doi: 10.1556/ABiol.55.2004.1-4.24.


In the pond snail Lymnaea stagnalis, D-glucose action was investigated on electrical activity of identified central neurons. In the CNS preparations isolated from specimens that starved for 24-96 h, D-glucose added to a standard or HiDi saline at 500-700 microg/ml effectively hyperpolarized ca. 90% of feeding related neurons B1, SO and CGC. However, not all feeding-related neurons examined were responsive to glucose. Experiments on cells of the serotonergic Pedal A cluster have shown that hyperpolarizing action of D-glucose is retained following complete isolation of "hunger" neurons. Threshold concentration producing 1-3 mV hyperpolarization was ca. 50 microg/ml. The results suggest a direct glucose involvement in the mechanisms that control feeding behavior in Lymnaea.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal
  • Central Nervous System / metabolism
  • Feeding Behavior
  • Glucose / metabolism
  • Glucose / pharmacology*
  • Nervous System Physiological Phenomena
  • Neurons / metabolism*
  • Snails
  • Sodium Chloride / pharmacology
  • Time Factors


  • Sodium Chloride
  • Glucose