New alkaloids and a tetraflavonoid from Cephalotaxus wilsoniana

J Nat Prod. 2004 Jul;67(7):1182-5. doi: 10.1021/np0498657.

Abstract

A new homoerythrina alkaloid, C-3-epi-wilsonione (1), a new tetraflavonoid, taiwanhomoflavone C (2), and a new stereoisomer of desmethylcephalotaxinone (3) have been isolated from the leaves and heartwood of Cephalotaxus wilsoniana, respectively. The structures were elucidated by spectroscopic methods. Compound 1 showed cytotoxic activity against a number of human cancer cell lines in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cephalotaxus / chemistry*
  • Drug Screening Assays, Antitumor
  • Epoxy Compounds / chemistry
  • Epoxy Compounds / isolation & purification*
  • Epoxy Compounds / pharmacology
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Humans
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Taiwan
  • Tumor Cells, Cultured

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • C-3-epi-wilsonione
  • Epoxy Compounds
  • Flavonoids
  • taiwanhomoflavone C