Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up

Epilepsia. 2004 Aug;45(8):960-2. doi: 10.1111/j.0013-9580.2004.42203.x.


Purpose: In a previous study we reported clinically significant memory declines 3 months after selective amygdalohippocampectomy (SAH) in 140 patients with mesial temporal lobe epilepsy, particularly if the resection was left-sided. We supposed that the observed postoperative impairments might have reflected acute effects of surgery. Therefore we evaluated in the present study whether a recovery can be found 1 year after surgery.

Methods: Verbal and nonverbal memory functions were assessed in 115 patients before and 3 and 12 months after unilateral SAH.

Results: No recovery of postoperative verbal memory declines was found in the left-SAH group. Clinically meaningful losses were still evident in 33 to 50% of patients. In right-SAH patients, a recovery of verbal memory was indicated, and effects of surgical complications were no longer evident. One year after surgery, the corresponding preoperative performance was the only significant predictor of a postoperative change in the left-SAH group.

Conclusions: Verbal memory decline observed 3 months after left SAH is persistent 1 year after surgery. Declines in verbal memory, which were observed in some right-SAH patients at the short-term follow-up, seem to be temporary.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Amygdala / surgery*
  • Epilepsy, Temporal Lobe / surgery*
  • Female
  • Follow-Up Studies
  • Functional Laterality / physiology*
  • Hippocampus / surgery*
  • Humans
  • Male
  • Memory Disorders / diagnosis*
  • Neuropsychological Tests
  • Postoperative Complications / diagnosis*
  • Prognosis
  • Temporal Lobe / surgery
  • Treatment Outcome
  • Verbal Learning / physiology