Biology of LPA in health and disease

Semin Cell Dev Biol. 2004 Oct;15(5):503-12. doi: 10.1016/j.semcdb.2004.05.003.


The functions of lysophosphatidic acid (LPA) can be broadly divided into two classes: (1) physiological and (2) pathological roles. The role of LPA in embryonic development can be seen as early as oocyte formation. It continues in postnatal homeostasis, through its ability to impart a level of protection from both stress and local injury, by regulating cellular proliferation, apoptosis, and the reorganization of cytoskeletal fibers. LPA may function as a double-edged sword. While it helps maintain homeostasis against stress and insult, it may also augment the development and spread of pathological processes, including cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / metabolism
  • Cardiovascular Physiological Phenomena
  • Female
  • Gastrointestinal Tract / physiology
  • Genitalia / physiology
  • Humans
  • Lysophospholipids / physiology*
  • Male
  • Nervous System Physiological Phenomena
  • Prostatic Neoplasms / metabolism


  • Lysophospholipids
  • lysophosphatidic acid