Milestones of neuronal development in the adult hippocampus

Trends Neurosci. 2004 Aug;27(8):447-52. doi: 10.1016/j.tins.2004.05.013.

Abstract

Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Biomarkers
  • Calbindin 2
  • Cell Division
  • Hippocampus / cytology
  • Hippocampus / growth & development*
  • Hippocampus / metabolism
  • Humans
  • Mice
  • Models, Neurological
  • Neuroglia / cytology*
  • Neuroglia / metabolism
  • Neurons / cytology*
  • Neurons / metabolism
  • S100 Calcium Binding Protein G / metabolism*
  • Stem Cells / classification
  • Stem Cells / cytology*
  • Stem Cells / metabolism

Substances

  • Biomarkers
  • Calbindin 2
  • S100 Calcium Binding Protein G