Corticostriatal plasticity: life after the depression

Trends Neurosci. 2004 Aug;27(8):460-7. doi: 10.1016/j.tins.2004.06.010.


Experience-dependent changes in corticostriatal transmission efficacy are likely to support the role of the striatum in reinforcement-based motor learning. Whereas long-term depression at glutamatergic corticostriatal synapses has long been regarded as the normal form of striatal plasticity, recent work provides evidence that use-dependent potentiation can naturally occur at these connections through an increase in both synaptic efficacy and postsynaptic intrinsic excitability. By decreasing the weight of cortical inputs required to fire striatal output neurons, short-term and long-term potentiation at corticostriatal connections can jointly participate in the formation of sensorimotor links by which specific context-dependent patterns of cortical activity can engage selected motor programs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / cytology
  • Cerebral Cortex / physiology*
  • Cortical Synchronization
  • Hippocampus / cytology
  • Hippocampus / physiology
  • Humans
  • Long-Term Synaptic Depression / physiology*
  • Membrane Potentials / physiology*
  • Neostriatum / cytology
  • Neostriatum / physiology*
  • Neuronal Plasticity / physiology
  • Neurons / physiology*
  • Psychomotor Performance / physiology