Abstract
While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Diphosphates / immunology*
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Diphosphates / metabolism
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Erythritol / analogs & derivatives*
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Erythritol / metabolism
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Humans
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Lymphocyte Activation / immunology*
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Mycoplasma / immunology
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Mycoplasma / metabolism
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Mycoplasma penetrans / genetics
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Mycoplasma penetrans / immunology*
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Receptors, Antigen, T-Cell, gamma-delta / metabolism*
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Sugar Phosphates / metabolism
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T-Lymphocytes / immunology*
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Terpenes / metabolism
Substances
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2-C-methylerythritol 4-phosphate
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4-hydroxy-3-methylbut-2-enyl pyrophosphate
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Diphosphates
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Receptors, Antigen, T-Cell, gamma-delta
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Sugar Phosphates
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Terpenes
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Erythritol