Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so

Infect Immun. 2004 Aug;72(8):4881-3. doi: 10.1128/IAI.72.8.4881-4883.2004.

Abstract

While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diphosphates / immunology*
  • Diphosphates / metabolism
  • Erythritol / analogs & derivatives*
  • Erythritol / metabolism
  • Humans
  • Lymphocyte Activation / immunology*
  • Mycoplasma / immunology
  • Mycoplasma / metabolism
  • Mycoplasma penetrans / genetics
  • Mycoplasma penetrans / immunology*
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • Sugar Phosphates / metabolism
  • T-Lymphocytes / immunology*
  • Terpenes / metabolism

Substances

  • 2-C-methylerythritol 4-phosphate
  • 4-hydroxy-3-methylbut-2-enyl pyrophosphate
  • Diphosphates
  • Receptors, Antigen, T-Cell, gamma-delta
  • Sugar Phosphates
  • Terpenes
  • Erythritol