Genetic clues to the pathogenesis of Parkinson's disease

Nat Med. 2004 Jul;10 Suppl:S58-62. doi: 10.1038/nm1068.

Abstract

Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the disorder.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Dopamine / metabolism
  • Genetic Predisposition to Disease*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Leukocyte Common Antigens / genetics
  • Leukocyte Common Antigens / metabolism
  • Models, Neurological
  • Mutation / genetics
  • Nerve Degeneration / genetics
  • Nerve Degeneration / pathology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism
  • Parkinson Disease / genetics*
  • Parkinson Disease / pathology
  • Protein Deglycase DJ-1
  • Synucleins
  • Ubiquitin-Protein Ligases / genetics*
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Intracellular Signaling Peptides and Proteins
  • Nerve Tissue Proteins
  • Oncogene Proteins
  • Synucleins
  • Ubiquitin-Protein Ligases
  • parkin protein
  • PARK7 protein, human
  • Protein Deglycase DJ-1
  • Leukocyte Common Antigens
  • Dopamine