Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing

Antimicrob Agents Chemother. 2004 Aug;48(8):3122-6. doi: 10.1128/AAC.48.8.3122-3126.2004.


In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

MeSH terms

  • Drug Resistance, Viral
  • Genotype
  • HIV Infections / virology*
  • HIV Protease / genetics*
  • HIV Protease Inhibitors / pharmacology
  • HIV Reverse Transcriptase / genetics*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation / genetics*
  • Reverse Transcriptase Inhibitors / pharmacology


  • HIV Protease Inhibitors
  • Reverse Transcriptase Inhibitors
  • HIV Reverse Transcriptase
  • HIV Protease