Abstract
A microbicide combining the lipid-ether 1-0-octyl-sn-glycerol (OG; 3 mM) and peptide D2A21 (9 microM) reduced herpes simplex virus type 1 (HSV-1) and HSV-2 titers by at least 1,000-fold, more than the sum of the inactivations produced by OG and D2A21 alone. OG plus D2A21 reduced HSV-1 and HSV-2 titers by > or =1,000-fold in < or =10 and < or =20 min, respectively, whereas OG and D2A21 used alone produced almost no virus inactivation during these times.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antimicrobial Cationic Peptides
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Antiviral Agents / pharmacology*
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Drug Combinations
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Glyceryl Ethers / pharmacology*
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Herpesvirus 1, Human / drug effects*
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Herpesvirus 2, Human / drug effects*
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Humans
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Peptides / pharmacology*
Substances
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1-O-octyl-sn-glycerol
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Antimicrobial Cationic Peptides
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Antiviral Agents
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D2A21
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Drug Combinations
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Glyceryl Ethers
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Peptides