Abstract
High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Electrophoresis, Polyacrylamide Gel
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Ertapenem
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Lactams*
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Microbial Sensitivity Tests
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Plasmids / genetics
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Porins / physiology*
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beta-Lactam Resistance
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beta-Lactamases / physiology*
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Lactams
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Porins
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beta-Lactams
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beta-Lactamases
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Ertapenem