Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae

Antimicrob Agents Chemother. 2004 Aug;48(8):3203-6. doi: 10.1128/AAC.48.8.3203-3206.2004.

Abstract

High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Electrophoresis, Polyacrylamide Gel
  • Ertapenem
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Lactams*
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Porins / physiology*
  • beta-Lactam Resistance
  • beta-Lactamases / physiology*
  • beta-Lactams / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Lactams
  • Porins
  • beta-Lactams
  • beta-Lactamases
  • Ertapenem