Structural organization of the genome of SARS-associated coronavirus (Strain SoD) isolated on the territory of the Russian Federation

G G Onishchenko; V M Govorun; V I Sergienko; T A Akopian; K T Momynaliev; V A Vereshchagin; V N Lazarev; N T Vasilev; V I Markov; V A Merkulov; V A Maksimov; V A Melnikov; Yu M Lopukhin

doi:10.1023/b:bebm.0000028139.02582.97

Structural organization of the genome of SARS-associated coronavirus (Strain SoD) isolated on the territory of the Russian Federation

Bull Exp Biol Med. 2004 Feb;137(2):197-9. doi: 10.1023/b:bebm.0000028139.02582.97.

[Article in English, Russian]

Authors

G G Onishchenko¹, V M Govorun, V I Sergienko, T A Akopian, K T Momynaliev, V A Vereshchagin, V N Lazarev, N T Vasilev, V I Markov, V A Merkulov, V A Maksimov, V A Melnikov, Yu M Lopukhin

Affiliation

¹ State Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, Russia. pathol@cyber.ma.nsc

Abstract

Complete nucleotide cDNA sequence (29715 nucleotides) of SARS-associated coronavirus (strain SoD) isolated for the first time in the territory of the Russian Federation was determined. Phylogenetic analysis revealed maximum similarity between strain SoD genome and Frankfurt 1 strain genome. Three nucleotide substitutions determining two amino acid substitutions were detected.

Publication types

Comparative Study

MeSH terms

Amino Acid Substitution
DNA, Complementary / genetics
DNA, Viral / genetics
Genome, Viral*
Humans
Phylogeny
Polymerase Chain Reaction
Russia
Severe Acute Respiratory Syndrome / virology
Severe acute respiratory syndrome-related coronavirus / classification
Severe acute respiratory syndrome-related coronavirus / genetics*
Severe acute respiratory syndrome-related coronavirus / isolation & purification*

Substances

DNA, Complementary
DNA, Viral