Simvastatin-induced mononeuropathy multiplex: case report

Arq Neuropsiquiatr. 2004 Jun;62(2B):540-2. doi: 10.1590/s0004-282x2004000300031. Epub 2004 Jul 20.


The association between the use of statins and neuromuscular disease is currently being intensely discussed. We relate a 63 years old man with possible case of statin-induced neuropathy in a patient with dislipidemia in use of simvastatina at high doses. The electrophysiologic studies disclosed findings compatible with mononeuropathy multiplex, suggested by clinical prescutation of asymmetrical numbness and weakness. More common causes of mononeuropathy multiplex were excluded and the patient improved after the discontinuation of the drug.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Male
  • Middle Aged
  • Mononeuropathies / chemically induced*
  • Mononeuropathies / diagnosis
  • Simvastatin / adverse effects*


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Simvastatin