Neonatal seizures

Pediatr Clin North Am. 2004 Aug;51(4):961-78, ix. doi: 10.1016/j.pcl.2004.03.002.


Neonatal seizures typically indicate significant underlying disease.They are poorly classified, under-recognized, and often difficult to treat. Recognition of etiology is often helpful in prognosis and treatment; the most common is hypoxic-ischemic encephalopathy. Patients generally have a poor prognosis, with most developing a severe encephalopathy and epilepsy. Studies suggest that neonatal seizures and their etiology have a significant impact on the developing brain; it is critical to recognize seizures early and initiate immediate antiepileptic therapy. Continuous computerized simultaneous video electroencephalograph monitoring is imperative;at-risk infants will frequently have electrographic seizures without clinical manifestations. Although there are antiepileptic therapies for neonatal seizures, they are ineffective in over 35% of cases. The goal of research should be the development of more effective therapies for neonatal seizures, regardless of etiology.

Publication types

  • Review

MeSH terms

  • Electroencephalography
  • Humans
  • Infant, Newborn
  • Seizures* / diagnosis
  • Seizures* / drug therapy
  • Seizures* / physiopathology
  • Treatment Outcome