MT1-MMP: An Enzyme With Multidimensional Regulation

Trends Biochem Sci. 2004 Jun;29(6):285-9. doi: 10.1016/j.tibs.2004.04.001.

Abstract

The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.

MeSH terms

  • Cell Membrane / physiology
  • Glycosylation
  • Humans
  • Hyaluronan Receptors / physiology
  • Matrix Metalloproteinases, Membrane-Associated
  • Membrane Proteins / antagonists & inhibitors
  • Membrane Proteins / metabolism*
  • Metalloendopeptidases / antagonists & inhibitors
  • Metalloendopeptidases / metabolism*

Substances

  • Hyaluronan Receptors
  • Membrane Proteins
  • Matrix Metalloproteinases, Membrane-Associated
  • Metalloendopeptidases