Emerging functions of BRCA2 in DNA recombination

Trends Biochem Sci. 2004 Jun;29(6):310-6. doi: 10.1016/j.tibs.2004.04.009.


Mutations in the breast cancer susceptibility protein BRCA2 cause inherited susceptibility to breast, ovarian and other cancers. There is now compelling experimental evidence that a major biological function of BRCA2 is the maintenance of chromosome structure stability in dividing cells by regulation of steps in recombination between homologous DNA strands. Recent experimental findings shape the current models for BRCA2 function, and structural and biochemical advances shed new light on the interactions between BRCA2, the RAD51 recombinase and single-stranded DNA during DNA recombination.

Publication types

  • Review

MeSH terms

  • Animals
  • BRCA2 Protein / physiology*
  • DNA / metabolism*
  • DNA-Binding Proteins / physiology
  • Evolution, Molecular
  • Humans
  • Protein Conformation
  • Rad51 Recombinase
  • Recombination, Genetic*


  • BRCA2 Protein
  • DNA-Binding Proteins
  • DNA
  • RAD51 protein, human
  • Rad51 Recombinase