Abstract
The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.
MeSH terms
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Anticonvulsants / adverse effects*
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Anticonvulsants / therapeutic use
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Child
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Drug Therapy, Combination
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Electroencephalography / drug effects
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Electromyography
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Epilepsy, Rolandic / drug therapy*
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Epilepsy, Rolandic / physiopathology
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Female
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Humans
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Lamotrigine
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Myoclonus / chemically induced*
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Seizures / chemically induced*
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Sleep Disorders, Intrinsic / drug therapy
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Sleep Disorders, Intrinsic / physiopathology
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Triazines / adverse effects*
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Triazines / therapeutic use
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Valproic Acid / therapeutic use
Substances
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Anticonvulsants
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Triazines
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Valproic Acid
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Lamotrigine