Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy

Neurology. 2004 Jul 27;63(2):373-5. doi: 10.1212/01.wnl.0000130195.62670.a6.

Abstract

The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Child
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Electromyography
  • Epilepsy, Rolandic / drug therapy*
  • Epilepsy, Rolandic / physiopathology
  • Female
  • Humans
  • Lamotrigine
  • Myoclonus / chemically induced*
  • Seizures / chemically induced*
  • Sleep Disorders, Intrinsic / drug therapy
  • Sleep Disorders, Intrinsic / physiopathology
  • Triazines / adverse effects*
  • Triazines / therapeutic use
  • Valproic Acid / therapeutic use

Substances

  • Anticonvulsants
  • Triazines
  • Valproic Acid
  • Lamotrigine