Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis

P A Keir; D M Brown; A Clouter-Baker; Y M Harcus; L Proudfoot

doi:10.1111/j.0141-9838.2004.00692.x

Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis

Parasite Immunol. 2004 Mar;26(3):137-9. doi: 10.1111/j.0141-9838.2004.00692.x.

Authors

P A Keir¹, D M Brown, A Clouter-Baker, Y M Harcus, L Proudfoot

Affiliation

¹ School of Life Sciences, Napier University, Edinburgh, UK.

PMID: 15279624
DOI: 10.1111/j.0141-9838.2004.00692.x

Abstract

It has been reported that excretory-secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune system. We observed that intratracheal instillation of ES from the L3 stage of the parasite reduced neutrophil numbers in LPS-induced inflammation as assessed by bronchoalveolar lavage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Helminth / administration & dosage
Female
Host-Parasite Interactions / immunology
Inflammation / etiology
Inflammation / prevention & control
Lipopolysaccharides / administration & dosage
Lung / immunology
Neutrophils / immunology*
Nippostrongylus / growth & development
Nippostrongylus / immunology*
Nippostrongylus / pathogenicity*
Rats
Rats, Wistar
Strongylida Infections / immunology

Substances

Antigens, Helminth
Lipopolysaccharides