Chk1 in the DNA damage response: conserved roles from yeasts to mammals

DNA Repair (Amst). Aug-Sep 2004;3(8-9):1025-32. doi: 10.1016/j.dnarep.2004.03.003.


Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. Studies to date have revealed striking similarities among Chk1 pathways of different organisms. In this review we discuss what is known about Chk1 activation and what downstream factors are regulated by Chk1 to counter replication blocks and DNA damage induced by UV, IR, and other genotoxic agents. Where applicable, we also compare the role of Chk1 with that of the Chk2 protein kinase in the checkpoint responses.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle
  • Cell Cycle Proteins / metabolism
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage*
  • DNA-Binding Proteins
  • Fungal Proteins / physiology
  • Humans
  • Models, Biological
  • Models, Molecular
  • Phosphorylation
  • Protein Kinases / genetics*
  • Protein Kinases / physiology*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology
  • S Phase
  • Tumor Suppressor Proteins
  • Ultraviolet Rays


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Fungal Proteins
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK1 protein, human
  • CHEK2 protein, human
  • Checkpoint Kinase 1
  • Protein-Serine-Threonine Kinases