Claspin, a regulator of Chk1 in DNA replication stress pathway

DNA Repair (Amst). Aug-Sep 2004;3(8-9):1033-7. doi: 10.1016/j.dnarep.2004.03.001.

Abstract

Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Adaptor Proteins, Signal Transducing / physiology*
  • Amino Acid Sequence
  • Animals
  • Cell Cycle
  • Checkpoint Kinase 1
  • DNA Damage*
  • DNA Repair*
  • Enzyme Activation
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Saccharomyces cerevisiae / physiology
  • Schizosaccharomyces / physiology
  • Schizosaccharomyces pombe Proteins
  • Xenopus
  • Xenopus Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • CLSPN protein, human
  • Schizosaccharomyces pombe Proteins
  • Xenopus Proteins
  • Protein Kinases
  • CHEK1 protein, human
  • Checkpoint Kinase 1
  • Chek1 protein, Xenopus
  • Chk1 protein, S pombe