Inhibition of metalloproteinase activity by fruit extracts

Cancer Lett. 2004 Aug 30;212(2):153-8. doi: 10.1016/j.canlet.2004.03.025.

Abstract

While the metalloproteinase enzymes are essential for development and remodeling of tissues, aberrant over expression of these enzymes contributes to several pathologic conditions. In particular, metalloproteinase over expression in cancer plays a significant role in metastasis by providing a mechanism for invasion and spread. The data presented here indicate that water extracts of raspberries, blackberries and muscadine grapes inhibit the activities of metalloproteinases 2 and 9. This inhibition could contribute to the suppression of carcinogenesis by diets high in fruit content.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anticarcinogenic Agents / pharmacology
  • Enzyme Inhibitors / pharmacology*
  • Flavonoids
  • Fruit / enzymology*
  • Matrix Metalloproteinase 2 / metabolism*
  • Matrix Metalloproteinase 9 / metabolism*
  • Metalloproteases / metabolism*
  • Phenols
  • Plant Extracts / pharmacology*
  • Polyphenols
  • Vitis / enzymology*

Substances

  • Anticarcinogenic Agents
  • Enzyme Inhibitors
  • Flavonoids
  • Phenols
  • Plant Extracts
  • Polyphenols
  • Metalloproteases
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9