Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Cancer Lett. 2004 Aug 30;212(2):253-9. doi: 10.1016/j.canlet.2004.03.016.


Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P = 0.015), lymphatic invasion (P = 0.033), lymph node metastasis (P = 0.015), and an advanced pTNM stage (P = 0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • Cadherins*
  • Carcinoma / metabolism*
  • Carcinoma / pathology
  • Carrier Proteins / biosynthesis*
  • Cell Differentiation
  • Cell Line, Tumor
  • Colorectal Neoplasms / metabolism*
  • Colorectal Neoplasms / pathology
  • Disease Progression
  • Female
  • Humans
  • Immunoblotting
  • Immunohistochemistry
  • Liver / metabolism
  • Lymphatic Metastasis
  • Male
  • Membrane Transport Proteins*
  • Middle Aged
  • Phenotype


  • Antibodies, Monoclonal
  • CDH17 protein, human
  • Cadherins
  • Carrier Proteins
  • Membrane Transport Proteins
  • intestinal peptide-proton cotransporter