Does random X-inactivation in mammals reflect a random choice between two X chromosomes?

Genetics. 2004 Jul;167(3):1525-8. doi: 10.1534/genetics.104.029819.


Inactivation of the maternal or paternal X chromosome in a mammalian embryonic XX cell is believed to involve random choice between the two X's. We propose two alternative models. One suggests that choice is not random, while the other is consistent with random choice, but not one between two X's.

Publication types

  • Comment
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dosage Compensation, Genetic*
  • Mammals / genetics*
  • Models, Biological*
  • Stochastic Processes*
  • X Chromosome / genetics*