Acquired disorders of elastic tissue: Part II. decreased elastic tissue

J Am Acad Dermatol. 2004 Aug;51(2):165-85; quiz 186-8. doi: 10.1016/j.jaad.2004.03.016.


Elastic fibers in the extracellular matrix are integral components of dermal connective tissue. The resilience and elasticity required for normal structure and function of the skin are attributable to the network of elastic tissue. Advances in our understanding of elastic tissue physiology provide a foundation for studying the pathogenesis of elastic tissue disorders. Many acquired disorders are nevertheless poorly understood owing to the paucity of reported cases. Several acquired disorders in which loss of dermal elastic tissue produces prominent clinical and histopathologic features have recently been described, including middermal elastolysis, papular elastorrhexis, and pseudoxanthoma-like papillary dermal elastolysis, which must be differentiated from more well-known disorders such as anetoderma, acquired cutis laxa, and acrokeratoelastoidosis. Learning objective At the conclusion of this learning activity, participants should have an understanding of the similarities and differences between acquired disorders of elastic tissue that are characterized by a loss of elastic tissue.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Connective Tissue Diseases / diagnosis*
  • Connective Tissue Diseases / etiology
  • Connective Tissue Diseases / pathology*
  • Connective Tissue Diseases / therapy
  • Diagnosis, Differential
  • Elastic Tissue / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Skin Diseases / diagnosis
  • Skin Diseases / drug therapy
  • Skin Diseases / etiology