Granuloma faciale: a clinicopathological study of 11 cases

J Am Acad Dermatol. 2004 Aug;51(2):269-73. doi: 10.1016/j.jaad.2003.11.071.


Background: Granuloma faciale is an uncommon disease of unknown etiology that is often misdiagnosed clinically and by general pathologists.

Objective: To describe the clinicopathological features of a series of patients with granuloma faciale.

Methods: Eleven patients diagnosed with granuloma faciale between 1990 and 2002 were included in the study.

Results: Granuloma faciale was diagnosed in 11 patients (9 male and 2 female, mean age 53.45 years). All of them presented facial cutaneous lesions and two of them also developed extrafacial lesions. Histologically, in 8 cases the infiltrate was limited to the upper half of the dermis. Two specimens showed fibrinoid necrosis. Concentric fibrosis around small blood vessels was demonstrated in 5 patients.

Conclusion: The presence of abundant fibrosis in 5 of our patients similar to that observed in erythema elevatum diutinum suggests that granuloma faciale and erythema elevatum diutinum may be produced by similar or the same pathogenic mechanism.

MeSH terms

  • Biopsy
  • Chronic Disease
  • Diagnosis, Differential
  • Erythema / pathology
  • Facial Dermatoses / pathology*
  • Female
  • Fibrosis / pathology
  • Granuloma / pathology*
  • Humans
  • Male
  • Middle Aged
  • Necrosis
  • Vasculitis / pathology