Synthesis and biological evaluation of caulibugulones A-E

Org Biomol Chem. 2004 Aug 7;2(15):2173-4. doi: 10.1039/b408184f. Epub 2004 Jul 5.

Abstract

The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Bryozoa / metabolism*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Isoquinolines / chemistry
  • Quinones / chemistry
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
  • cdc25 Phosphatases / antagonists & inhibitors
  • cdc25 Phosphatases / metabolism

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Isoquinolines
  • Quinones
  • cdc25 Phosphatases