Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger

J Environ Pathol Toxicol Oncol. 1999;18(2):131-9.

Abstract

Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including [6]-gingerol and [6]-paradol, and has been reported to possess a strong anti-inflammatory activity. These pungent substances have a vanilloid structure found in other chemopreventive phytochemicals, including curcumin. In our study, we found anti-tumor-promoting properties of [6]-gingerol and [6]-paradol. Thus, topical application of [6]-gingerol or [6]-paradol 30 min prior to 12-O-tetradecanoyl-phorbol-13-acetate (TPA) attenuated the skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene in female ICR mice. These substances also significantly inhibited the tumor-promoter-stimulated inflammation, TNF-alpha production, and activation of epidermal ornithine decarboxylase in mice. In another study, [6]-gingerol and [6]-paradol suppressed the superoxide production stimulated by TPA in differentiated HL-60 cells. Taken together, these findings suggest that pungent vanilloids found in ginger possess potential chemopreventive activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Carcinogens / toxicity
  • Catechols
  • Dermatitis / etiology
  • Dermatitis / pathology
  • Dermatitis / prevention & control
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / pharmacology*
  • Female
  • Ginger / chemistry*
  • Guaiacol / analogs & derivatives*
  • Guaiacol / chemistry
  • Guaiacol / pharmacology*
  • HL-60 Cells / drug effects
  • HL-60 Cells / metabolism
  • Humans
  • Ketones / chemistry
  • Ketones / pharmacology*
  • Mice
  • Mice, Inbred ICR
  • Ornithine Decarboxylase / metabolism
  • Papilloma / chemically induced
  • Papilloma / pathology
  • Papilloma / prevention & control
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Skin / drug effects
  • Skin / enzymology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / pathology
  • Skin Neoplasms / prevention & control
  • Superoxides / metabolism
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anticarcinogenic Agents
  • Carcinogens
  • Catechols
  • Fatty Alcohols
  • Ketones
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • Superoxides
  • Guaiacol
  • gingerol
  • 6-paradol
  • Ornithine Decarboxylase
  • Tetradecanoylphorbol Acetate