PPAR alpha, fibrates, lipid metabolism and inflammation

Arch Mal Coeur Vaiss. 2004 Jun;97(6):665-72.

Abstract

Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors belonging to the nuclear receptor superfamily. Three PPAR isotypes have been characterised: alpha, beta/delta and gamma. Identification of selective ligands and gene targeting studies have allowed determination of subtype-specific functions and the therapeutic potential of these receptors. Thus, PPAR alpha plays a prominent role in several physiological processes including the control of lipid and lipoprotein metabolism, glucose homoeostasis and the inflammatory response. Here, we update the potential of PPAR alpha activation in the treatment of metabolic disorders and related cardiovascular complications.

Publication types

  • Review

MeSH terms

  • Arteriosclerosis / physiopathology
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / therapy
  • Fatty Acids / metabolism
  • Gene Expression
  • Glucose / metabolism
  • Humans
  • Inflammation*
  • Ligands
  • Lipid Metabolism*
  • Metabolic Diseases / complications
  • Metabolic Diseases / drug therapy*
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Transcription Factors / pharmacology
  • Transcription Factors / physiology*

Substances

  • Fatty Acids
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Glucose