Occurrence of t(8;22)(q24.1;q11.2) involving the MYC locus in a case of pediatric acute lymphoblastic leukemia with a precursor B cell immunophenotype

J Pediatr Hematol Oncol. 2004 Aug;26(8):532-4. doi: 10.1097/01.mph.0000132736.31514.28.


The authors describe a child with clinical presentation of acute leukemia and an immunophenotype consistent with precursor B-cell acute lymphoblastic leukemia. However, the lymphoblasts had atypical L3 features and the chromosome rearrangement t(8;22)(q24.1;q11.2) involving the MYC locus. The cytogenetic features in this patient were characteristic of mature B/Burkitt leukemia and led to modulation of therapy. This case highlights the need for timely cytogenetic and molecular studies in the diagnosis of acute leukemia.

Publication types

  • Case Reports

MeSH terms

  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Child
  • Chromosomes, Human, Pair 22 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Female
  • Gene Rearrangement
  • Genes, myc*
  • Humans
  • Immunophenotyping
  • Karyotyping
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Translocation, Genetic*