Sensitivity of splenic and bone marrow aspirate study for diagnosis of kala-azar

Mymensingh Med J. 2004 Jul;13(2):130-3.


Fifty adult patients of kala-azar were included in this prospective study from Medicine Unit-I of Mymensingh Medical College Hospital. Splenic and bone marrow aspiration were done simultaneously to compare the sensitivity and other related merits and demerits of each procedure. Splenic aspiration appeared to be more sensitive procedure than bone marrow aspiration. Leishman - Donovan (LD) bodies were found in 90 percent and 72 percent of the spleen and bone marrow aspirates respectively. Splenic aspiration was found more acceptable to patients (96%) as it was less painful. Both the procedures were hazardless. There was no major complication except mild pain after splenic aspiration; even a few patients had history of epistaxis. Splenic aspiration was also more acceptable by the physicians because of an easy and reliable diagnostic procedure.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Biopsy, Fine-Needle*
  • Bone Marrow / parasitology*
  • Female
  • Humans
  • Leishmania donovani / isolation & purification*
  • Leishmaniasis, Visceral / diagnosis*
  • Male
  • Middle Aged
  • Sensitivity and Specificity
  • Spleen / parasitology*