Immunoreactive transforming growth factor-alpha and epidermal growth factor in colorectal adenomas and carcinomas

Oncology. 1992;49(5):381-5. doi: 10.1159/000227077.


A total of 117 colorectal tissue specimens were examined immunohistochemically for the production of immunoreactive (IR-) transforming growth factor (TGF)-alpha and IR-epidermal growth factor (EGF). IR-TGF-alpha was detected in 26/32 (81.3%) invasive cancers, 14/27 (51.9%) carcinomas in situ, and 14/58 (24.1%) adenomas. IR-EGF was detected in 14/32 (43.8%) invasive cancers, 12/27 (44.4%) carcinomas in situ, and 12/58 (20.7%) adenomas. The staining intensity of IR-TGF-alpha was related to the histologic grade of malignancy, but that of IR-EGF was not. These suggest that IR-TGF-alpha plays a more important role than IR-EGF in the growth of colorectal neoplasms, and that further study of these growth factors would be helpful in understanding the biology of colorectal carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / metabolism*
  • Carcinoma / metabolism*
  • Carcinoma in Situ / metabolism
  • Colorectal Neoplasms / metabolism*
  • Epidermal Growth Factor / metabolism*
  • Humans
  • Immunohistochemistry
  • Transforming Growth Factor alpha / metabolism*


  • Transforming Growth Factor alpha
  • Epidermal Growth Factor