Abstract
Pulmonary fibrosis is a devastating condition that leads to progressive lung destruction and scarring. Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease.
Publication types
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Comment
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bleomycin / toxicity
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Fibroblasts / pathology
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Genetic Predisposition to Disease
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Humans
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Inflammation / metabolism
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Inflammation / pathology
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Lung Injury*
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Models, Biological
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Pulmonary Fibrosis / chemically induced
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Pulmonary Fibrosis / genetics
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Pulmonary Fibrosis / metabolism*
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Pulmonary Fibrosis / pathology
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Pulmonary Fibrosis / physiopathology*
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Wound Healing