A soluble-polymer system for the asymmetric transfer hydrogenation of ketones

Stephanie Bastin; Richard J Eaves; Christopher W Edwards; Osamu Ichihara; Mark Whittaker; Martin Wills

doi:10.1021/jo049479u

A soluble-polymer system for the asymmetric transfer hydrogenation of ketones

J Org Chem. 2004 Aug 6;69(16):5405-12. doi: 10.1021/jo049479u.

Authors

Stephanie Bastin¹, Richard J Eaves, Christopher W Edwards, Osamu Ichihara, Mark Whittaker, Martin Wills

Affiliation

¹ Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

PMID: 15287789
DOI: 10.1021/jo049479u

Abstract

The appropriate combination of methacrylate polymers permits the synthesis of a soluble polymer for use in ruthenium(II)-catalyzed asymmetric transfer hydrogenation reactions. Using a 7:3 copolymer of a poly(ethylene glycol) ester and a hydroxyethyl ester, a derived ruthenium(II)/norephedrine complex catalyses reduction of acetophenone in up to 95% yield and 81% ee.