Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity

Yael Oppenheim; Yoshiyuki Ban; Yaron Tomer

doi:10.1016/j.autrev.2004.03.003

Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity

Autoimmun Rev. 2004 Jul;3(5):388-93. doi: 10.1016/j.autrev.2004.03.003.

Authors

Yael Oppenheim¹, Yoshiyuki Ban, Yaron Tomer

Affiliation

¹ Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, P.O. Box 1055, One Gustave L. Levy Place, New York, NY 10029, USA.

PMID: 15288006
DOI: 10.1016/j.autrev.2004.03.003

Abstract

Interferon (IFN) alpha treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-alpha initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Antiviral Agents / adverse effects*
Disease Models, Animal
Humans
Interferons / adverse effects*
Risk Factors
Thyroiditis, Autoimmune / chemically induced*
Thyroiditis, Autoimmune / immunology

Substances

Antiviral Agents
Interferons

Abstract

Publication types

MeSH terms

Substances

Grants and funding