Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity

Autoimmun Rev. 2004 Jul;3(5):388-93. doi: 10.1016/j.autrev.2004.03.003.


Interferon (IFN) alpha treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-alpha initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / adverse effects*
  • Disease Models, Animal
  • Humans
  • Interferons / adverse effects*
  • Risk Factors
  • Thyroiditis, Autoimmune / chemically induced*
  • Thyroiditis, Autoimmune / immunology


  • Antiviral Agents
  • Interferons