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. 2004 Aug 10;101(32):11725-30.
doi: 10.1073/pnas.0402374101. Epub 2004 Aug 2.

Breed Distribution and History of Canine mdr1-1Delta, a Pharmacogenetic Mutation That Marks the Emergence of Breeds From the Collie Lineage

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Free PMC article

Breed Distribution and History of Canine mdr1-1Delta, a Pharmacogenetic Mutation That Marks the Emergence of Breeds From the Collie Lineage

Mark W Neff et al. Proc Natl Acad Sci U S A. .
Free PMC article

Abstract

A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele, mdr1-1Delta, segregated in seven additional breeds, including two sighthounds that were not expected to share collie ancestry. A mutant haplotype that was conserved among affected breeds indicated that the allele was identical by descent. Based on breed histories and the extent of linkage disequilibrium, we conclude that all dogs carrying mdr1-1Delta are descendants of a dog that lived in Great Britain before the genetic isolation of breeds by registry (ca. 1873). The breed distribution and frequency of mdr1-1Delta have applications in veterinary medicine and selective breeding, whereas the allele's history recounts the emergence of formally recognized breeds from an admixed population of working sheepdogs.

Figures

Fig. 1.
Fig. 1.
The Collie Family Tree, a composite of anecdotal breed histories (adapted with permission from L. Rorem). The diagram depicts reported historical relationships among contemporary herding breeds that share the collie lineage out of Great Britain. The breeds shown were selectively surveyed for the presence of mdr1-1Δ. Breeds that segregated the mutation are shown with an asterisk.
Fig. 2.
Fig. 2.
Genetic map of the MDR1 region of CFA14. The order of loci was established by radiation hybrid analysis. The confidence intervals (95%) for linkage distances are listed in parentheses. An asterisk denotes previously reported distances (25).

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