Mechanotransduction and the regulation of protein synthesis in skeletal muscle

Proc Nutr Soc. 2004 May;63(2):331-5. doi: 10.1079/PNS2004357.


Repeated bouts of resistance exercise produce an increase in skeletal muscle mass. The accumulation of protein associated with the growth process results from a net increase in protein synthesis relative to breakdown. While the effect of resistance exercise on muscle mass has long been recognized, the mechanisms underlying the link between high-resistance contractions and the regulation of protein synthesis and breakdown are, to date, poorly understood. In the present paper skeletal muscle will be viewed as a mechanosensitive cell type and the possible mechanisms through which mechanically-induced signalling events lead to changes in rates of protein synthesis will be examined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Exercise / physiology*
  • Humans
  • Hypertrophy
  • Muscle Contraction / physiology*
  • Muscle Proteins / biosynthesis*
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / physiology
  • Protein Biosynthesis / physiology*
  • Weight Lifting / physiology


  • Muscle Proteins