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Comparative Study
, 43 (3), 415-25

Prefrontal Neurons Coding Suppression of Specific Saccades

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Comparative Study

Prefrontal Neurons Coding Suppression of Specific Saccades

Ryohei P Hasegawa et al. Neuron.

Abstract

The prefrontal cortex has been implicated in the suppression of unwanted behavior, based upon observations of humans and monkeys with prefrontal lesions. Despite this, there has been little direct neurophysiological evidence for a mechanism that suppresses specific behavior. In this study, we used an oculomotor delayed match/nonmatch-to-sample task in which monkeys had to remember a stimulus location either as a marker of where to look or as a marker of where not to look. We found a group of neurons in both the frontal eye field and the caudal prefrontal cortex that carried signals selective for the forbidden stimulus. The activity of these "don't look" neurons correlated with the monkeys' success or failure on the task. These results demonstrate a frontal signal that is related to the active suppression of one action while the subject performs another.

Comment in

  • Don't Go There
    LH Snyder et al. Neuron 43 (3), 297-9. PMID 15294137. - Review
    Response inhibition, or impulse control, is critical for normal cognitive function. In this issue of Neuron, Hasegawa and colleagues use a spatial nonmatch-to-sample task …

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