Stachyose extract from Rehmannia glutinosa Libosch. to lower plasma glucose in normal and diabetic rats by oral administration

Pharmazie. 2004 Jul;59(7):552-6.


The hypoglycemic effects of water extract and stachyose extract (Part III) from Rehmannia glutinosa Libosch. were investigated in this paper by oral administration to normal, glucose- and adrenaline-induced hyperglycemic and alloxan-induced diabetic rats. The results showed that Part III had the effect of lowering fasted plasma glucose level and partially preventing hyperglycemia induced by glucose (2.5 g x kg(-1), i.p.) and adrenaline (300 microg x kg(-1), i.p.), respectively, but no obvious dose-dependent effect was found when it was administered at the doses of 100, 200 and 400 mg x kg(-1) for 6 days, i.g. In alloxan-induced diabetic rats, Part III (200 mg x kg(-1) for 15 days, i.g.) gave a significant decrease in blood glucose level. The results suggested that Part III, which is mainly composed of stachyose from Rehmannia glutinosa Libosch., had a significant hypoglycemic effect in glucose- and adrenaline-induced hyperglycemic and alloxan-induced diabetic rats.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Glucose / metabolism*
  • Body Weight / drug effects
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / metabolism*
  • Epinephrine
  • Female
  • Hyperglycemia / blood
  • Hyperglycemia / chemically induced
  • Hyperglycemia / drug therapy
  • Hypoglycemic Agents* / administration & dosage
  • Oligosaccharides / administration & dosage
  • Oligosaccharides / pharmacology*
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar
  • Rehmannia / chemistry*
  • Water


  • Blood Glucose
  • Hypoglycemic Agents
  • Oligosaccharides
  • Plant Extracts
  • Water
  • stachyose
  • Epinephrine