Emerging asymmetry and embryonic patterning in early mouse development

Dev Cell. 2004 Aug;7(2):155-64. doi: 10.1016/j.devcel.2004.07.012.


Recent studies have revealed asymmetries in the mouse zygote and preimplantation embryo, well before the establishment of anterior-posterior polarity after implantation. Whether these asymmetries are causally related to embryonic patterning or are coincidental outcomes of the topology of normal development remains uncertain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blastocyst / physiology
  • Body Patterning
  • Cell Nucleus / metabolism
  • Embryo Implantation
  • Female
  • Gastrula / metabolism
  • Gene Expression Regulation, Developmental*
  • Mice
  • Models, Biological
  • Time Factors
  • Uterus / physiology
  • Zygote / physiology