Multicenter evaluation of a new screening test that detects Clostridium difficile in fecal specimens

J Clin Microbiol. 2004 Aug;42(8):3837-40. doi: 10.1128/JCM.42.8.3837-3840.2004.

Abstract

Clostridium difficile causes approximately 25% of nosocomial antibiotic-associated diarrheas and most cases of pseudomembranous colitis. We evaluated C. DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile. Our results showed that this test was comparable to PCR in sensitivity and specificity and outperformed bacterial culture.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Biomarkers / analysis
  • Clostridioides difficile / enzymology
  • Clostridioides difficile / genetics
  • Clostridioides difficile / isolation & purification*
  • Cross Infection / diagnosis
  • Cross Infection / microbiology
  • Cross Infection / prevention & control
  • Diarrhea / diagnosis
  • Diarrhea / microbiology
  • Diarrhea / prevention & control
  • Enterocolitis, Pseudomembranous / diagnosis*
  • Enterocolitis, Pseudomembranous / prevention & control
  • Feces / microbiology*
  • Glutamate Dehydrogenase / analysis*
  • Humans
  • Mass Screening / methods
  • Polymerase Chain Reaction / methods
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • Glutamate Dehydrogenase