Pancreatitis caused by rheolytic thrombolysis: an unexpected complication

J Vasc Interv Radiol. 2004 Aug;15(8):857-60. doi: 10.1097/01.RVI.0000136994.66646.2F.


Two patients developed acute pancreatitis after mechanical thrombolysis with use of the AngioJet system. Patient 1 had undergone a remote complex revascularization of the lower extremities and presented with acute ischemia after thrombosis of his composite distal bypass. Patient 2 presented with superior vena cava (SVC) syndrome and had thrombosis of the SVC and innominate veins. Despite dissimilar presentations, both patients had renal insufficiency, were treated with mechanical and chemical thrombolysis, and had extensive thrombus burden. The pathophysiology of acute pancreatitis in this setting is believed to be secondary to massive hemolysis in the presence of chronic renal insufficiency. This phenomenon should be considered in patients whom develop abdominal pain after mechanical thrombolysis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Female
  • Fibrinolytic Agents / adverse effects
  • Humans
  • Ischemia / diagnostic imaging
  • Ischemia / drug therapy
  • Lower Extremity / blood supply
  • Lower Extremity / diagnostic imaging
  • Male
  • Middle Aged
  • Pancreatitis / etiology*
  • Recombinant Proteins / adverse effects
  • Renal Insufficiency, Chronic / complications
  • Renal Insufficiency, Chronic / diagnostic imaging
  • Renal Insufficiency, Chronic / drug therapy
  • Superior Vena Cava Syndrome / diagnostic imaging
  • Superior Vena Cava Syndrome / drug therapy
  • Thrombolytic Therapy / adverse effects*
  • Tissue Plasminogen Activator / adverse effects
  • Tomography, X-Ray Computed


  • Fibrinolytic Agents
  • Recombinant Proteins
  • reteplase
  • Tissue Plasminogen Activator