Advances in the Early Detection of Alzheimer's Disease

Nat Med. 2004 Jul;10 Suppl:S34-41. doi: 10.1038/nrn1433.


The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated 'mild cognitive impairment', emphasizing work on the early cognitive profile and associated neuroimaging studies.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / pathology*
  • Alzheimer Disease / physiopathology
  • Animals
  • Biomarkers
  • Cognition Disorders / etiology
  • Cognition Disorders / pathology
  • Dementia / etiology
  • Dementia / pathology
  • Diagnostic Imaging
  • Disease Progression
  • Early Diagnosis*
  • Humans
  • Neuropsychological Tests


  • Biomarkers