Persistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1

Hum Immunol. 2004 Jul;65(7):745-51. doi: 10.1016/j.humimm.2004.05.001.

Abstract

The aim of this study was to define novel associations between human leukocyte antigen (HLA) class 1 alleles and persistence or clearance of the hepatitis C virus (HCV) in a white population. All individuals in the study were seropositive for anti-HCV antibodies. Viral status was determined by the Roche HCV Amplicor test. HLA-A, -B, -C allelic group profile was molecularly defined by reverse line probe hybridization. The strongest individual allelic group associations with persistent HCV infection were HLA A*11 (p = 0.044) and Cw*04 (p = 0.006). However, only the HLA C*04 association survived correction for multiple comparisons. Further analysis of alleles in linkage with HLA Cw*04 revealed that the haplotype HLA A*11, Cw*04 was present in 11 individuals, 10 of whom were viremic (p = 0.05). No gene dosage effect was observed. No association between HLA class 1 allelic groups and aviremia and virus load was evident in this white population. HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. Novel HLA class 1 alleles associated with persistence of HCV have been identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / genetics
  • DNA / isolation & purification
  • Data Interpretation, Statistical
  • European Continental Ancestry Group / genetics*
  • Female
  • Gene Frequency / genetics
  • Genotype
  • HLA-A Antigens / genetics
  • HLA-B Antigens / genetics
  • HLA-C Antigens / genetics
  • Haplotypes / genetics
  • Hepacivirus / genetics
  • Hepacivirus / immunology
  • Hepatitis C, Chronic / blood
  • Hepatitis C, Chronic / genetics*
  • Hepatitis C, Chronic / immunology
  • Heterozygote
  • Histocompatibility Antigens Class I / genetics*
  • Homozygote
  • Humans
  • Ireland
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Viral Load

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class I
  • DNA