Jasmonic Acid Prevents the Accumulation of Cyclin B1;1 and CDK-B in Synchronized Tobacco BY-2 Cells

FEBS Lett. 2004 Aug 13;572(1-3):118-22. doi: 10.1016/j.febslet.2004.07.018.

Abstract

Jasmonic acid (JA) plays a crucial role in plant fertility and defense responses. It exerts an inhibitory effect on plant growth when applied exogenously. This effect seems to be somehow related to a negative regulation of cell cycle progression in the meristematic tissues. In this report, we focus on the molecular events that occur during JA-induced G2 arrest. We demonstrate that JA prevents the accumulation of B-type cyclin-dependent kinases and the expression of cyclin B1;1, which are both essential for the initiation of mitosis. This feature suggests the existence of an early G2 checkpoint that is affected by JA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aphidicolin / metabolism
  • Cell Cycle / drug effects*
  • Cell Line
  • Cyclin B / drug effects
  • Cyclin B / metabolism*
  • Cyclin B1
  • Cyclin-Dependent Kinases / drug effects
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclopentanes / pharmacology*
  • Kinetics
  • Oxylipins
  • Plant Growth Regulators / pharmacology
  • Tobacco / chemistry*
  • Tobacco / drug effects
  • Tobacco / enzymology

Substances

  • Cyclin B
  • Cyclin B1
  • Cyclopentanes
  • Oxylipins
  • Plant Growth Regulators
  • Aphidicolin
  • jasmonic acid
  • Cyclin-Dependent Kinases