Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis

FEBS Lett. 2004 Aug 13;572(1-3):135-40. doi: 10.1016/j.febslet.2004.07.023.


We have analyzed transcription profiles in peripheral blood CD3(+) cells from patients with allergic diseases to better understand the genes that are involved. Transcription levels of the gene KIAA0603/AS160 in CD3(+) cells from patients with atopic dermatitis (AD) were significantly higher than in normal individuals. The KIAA0603 gene encodes a 1299 amino acid protein with two phosphotyrosine interaction domains at the N-terminal region and a TBC domain at the C-terminal region. The region containing the TBC domain has a 31% homology to human rab6 GTPase activating protein (GAP). When human primary CD3(+) cells were stimulated with anti-CD3 or calcium ionophore, the KIAA0603 transcript level was upregulated. The marked upregulation of KIAA0607 was accompanied by activation induced cell death of primary CD3+ cells. KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells, especially helper memory T cells. Expression of KIAA0603 in T cells may be involved in pathogenesis of AD.

Publication types

  • Comparative Study

MeSH terms

  • Base Sequence
  • DNA Primers
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / metabolism*
  • GTPase-Activating Proteins / genetics*
  • GTPase-Activating Proteins / metabolism
  • Gene Expression Regulation / genetics*
  • Humans
  • Polymerase Chain Reaction / methods
  • Reference Values
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism*
  • Transcription, Genetic / genetics*
  • rab GTP-Binding Proteins / genetics*
  • rab GTP-Binding Proteins / metabolism


  • DNA Primers
  • GTPase-Activating Proteins
  • TBC1D4 protein, human
  • rab GTP-Binding Proteins